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Study: Enhancing cancer response to radiation

Research in a mouse model shows microRNAs have the potential to one day influence cancer treatment
Promising microRNA study
Postdoctoral researcher Cristina Espinosa runs an experiment, November 16, 2016. The early evidence found in research at OHSU by Espinosa, Dr. Sudarshan Anand and his team is promising, suggesting there may be a panel of microRNA that can be used as a biomarker for radiation therapy for many types of cancer in the future.(OHSU/Kristyna Wentz-Graff)

OHSU researcher Sudarshan Anand, Ph.D., has a contemporary analogy to describe microRNA: “I sometimes compare MicroRNA to tweets — they’re short, transient and constantly changing.”

Because microRNA is dynamic, it makes for a compelling target for cancer research.

Anand, an assistant professor of radiation medicine in the School of Medicine and member of the Knight Cancer Institute, teamed up with a group of researchers to take a closer look at microRNA in the context of the tumor microenvironment.

Sudarshan Anand
Dr. Sudarshan Anand (OHSU/Kristyna Wentz-Graff)

Their findings, published in Nature Communications, provide early evidence that a panel of microRNA may be used in the future as a biomarker for several types of cancer. Using a mouse model, Anand and colleagues demonstrated how microRNAs in the tumor microenvironment play a critical role in tumor progression and response to radiation therapy. With microRNAs, the team mimicked features of the autoimmune disease lupus within cancers to provoke an immune response.

“Biology is such a random process,” Anand says. “Two neighboring cells won’t always act the same way, just like two people don’t react the same way when they see the same event. We hope we will one day be able to read microRNAs and predict if a person’s cancer is going to respond to radiation.”This promising, early research may one day translate to human cancer radiation and treatment, and begs the question: Can we use microRNA biomarkers to influence cancer radiation? Anand and team believe it is a line of inquiry worth pursuing.

More information about this paper can be found on the OHSU Knight Cancer Institute’s science blog, Cancer Translated.

This research was funded by: National Heart Lung Blood Institute (NHLBI)/NIH, grant R00HL112962, and the Barbara-Ann Miller Dive for the Cure Award from the OHSU Knight Cancer Institute.

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