Study raises new alarm over long-term exposure to second-hand smoke

Research
Secondhand smoke
Secondhand smoke
Close up of a person smoking a cigarette (only nose, mouth and hand visible) with smoke around them and a blurred background
New research in mice from OHSU suggests long-term exposure to second-hand smoke can cause serious health effects. (Getty Images)

Chronic exposure to second-hand smoke results in lower body weight and cognitive impairments that more profoundly affects males, according to new research in mice led by Oregon Health & Science University.

The study published today in the journal Environmental Health Perspectives.

Close-up headshot of Jacob Raber, Ph.D., a man with short white hair, a grey moustache and black eyebrows
Jacob Raber, Ph.D.

“The hope is that we can better understand these effects for policymakers and the next generation of smokers,” said lead author Jacob Raber, Ph.D., professor of behavioral neuroscience in the OHSU School of Medicine. “Many people still smoke, and these findings suggest that the long-term health effects can be quite serious for people who are chronically exposed to second-hand smoke.”

The research examined daily exposure of 62 mice over a period of 10 months. Researchers used a specially designed “smoking robot” that went through a pack of cigarettes a day in ventilated laboratory space at OHSU. The longest previous study of this kind lasted three months.

“Nobody has done this, ever. This study is unique,” Raber said. “It really gives you the ability to look at long-term effects.”

“This study more accurately replicates the human experience by daily exposing mice to cigarette smoke,” added senior author Glen Kisby, Ph.D., professor of pharmacology at Western University of Health Sciences in Lebanon, Oregon.

Second-hand smoke is already considered a risk factor for dementia in people, but the new study put the theory to the test.

Researchers first divided mice into two groups – one wild-type and one expressing the human tau protein, important in Alzheimer’s-like dementia. Starting in April of 2018, they exposed mice to cigarette smoke for 168 minutes a day, then conducted behavioral and cognitive testing. They also examined lung and brain tissue.

Key findings:

Although smoking rates have declined in recent generations in some countries, smoking – and exposure to second-hand smoke – remains widespread in much of the world. The World Health Organization estimates 1.5 to 1.9 billion people worldwide will be smokers in 2025.

“Long-term exposure to second-hand smoke triggers detrimental changes,” Raber said. “Based on our study, it seems that males might be more susceptible than females. People should take that into consideration.”

In addition to Raber and Kisby, co-authors included Fred Stevens, Ph.D., professor of pharmaceutical sciences in the Linus Pauling Institute at Oregon State University; Gerd Bobe, Ph.D., associate professor of agricultural sciences in the Linus Pauling Institute at OSU; Arthur Penn, Ph.D., professor of comparative biomedical sciences at Louisiana State University; Alexandra Noël, Ph.D., assistant professor of comparative biomedical sciences at Louisiana State; and Michael Bartlett, Ph.D., professor of pharmacy at the University of Georgia.

The research was supported by the National Institutes of Health, grants R21 ES027943, T32 AG055378 and S10RR0287878, and the National Science Foundation, grant GVPRS0015A.


Erik Robinson
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