Korthuis is a general internist, addiction medicine specialist, and clinician scientist. He began his clinical career treating patients living with HIV and has practiced addiction medicine since 2004. He serves as Head of the Section of Addiction Medicine at OHSU.

His research focuses on integration of addiction treatment and prevention in diverse health care settings. He serves as co-principal investigator of the National Drug Abuse Treatment Clinical Trials Network Western States Node that tests new treatment strategies for opioid, methamphetamine, and cocaine use disorders. He has served as principal investigator for multiple National Institutes of Health-funded research studies, including the Oregon HOPE peer engagement intervention to decrease overdose in rural Oregon.

Honors include the 2008 Lawrence S. Linn Award for research that improves the lives of people living with HIV; a 2012-2013 Fulbright Scholar award to study integration of HIV and addiction care in Vietnam; and a 2022 Fulbright Senior Scholar Award to study the intersection of harm reduction and substance use disorder treatment in Barcelona, Spain.

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