Deseret News
August 06, 2025
In a Deseret News article about University of Utah research that suggests the genetic tool kit that enables animals like bears to survive hibernation could also exist in humans, Domenico Tupone, Ph.D., discusses an OHSU study that identified a brain-based mechanism called thermoregulatory inversion, a process that allows animals to lower their core body temperature without triggering the usual warming responses like shivering or burning a specific type of fat in the body; he says: “The idea is to reduce the body temperature to a lower level so that tissues like the brain or heart don’t need as much oxygen. That could improve outcomes from strokes or heart attacks. If we had a mechanism that allows us to transform humans into hibernating animals, we could achieve and control therapeutic hypothermia much better.”