Coverage continues on an OHSU study that developed a first-of-its-kind method to predict cancer patient survival using advanced molecular data from individual cells. Tao Ren, Ph.D., says, “This is the first kind of single-cell survival analysis that directly links individual tumor cells to patient outcomes.”

Coverage continues on an OHSU study that developed a first-of-its-kind method to predict cancer patient survival using advanced molecular data from individual cells. Tao Ren, Ph.D., says, “This is the first kind of single-cell survival analysis that directly links individual tumor cells to patient outcomes”

OPB Think Out Loud interviews Luiz Bertassoni, D.D.S., about OHSU’s pioneering work in 3D printing cancer cells from a patient and miniature versions of organs like bones and lungs.

OHSU researchers develop a first-of-its-kind AI-powered tool called scSurvival that analyzes genetic data from individual tumor cells — rather than averaging signals across an entire tumor — to more accurately predict cancer patient survival and identify specific cell populations linked to better or worse outcomes, potentially paving the way for more personalized cancer treatment. Tao Ren, Ph.D., says, “This is the first kind of single-cell survival analysis that directly links individual tumor cells to patient outcomes.”

OHSU researchers develop a first-of-its-kind AI-powered tool called scSurvival that analyzes genetic data from individual tumor cells — rather than averaging signals across an entire tumor — to more accurately predict cancer patient survival and identify specific cell populations linked to better or worse outcomes, potentially paving the way for more personalized cancer treatment. Tao Ren, Ph.D., says, “This is the first kind of single-cell survival analysis that directly links individual tumor cells to patient outcomes”

OHSU researchers develop a first-of-its-kind AI-powered tool called scSurvival that analyzes genetic data from individual tumor cells — rather than averaging signals across an entire tumor — to more accurately predict cancer patient survival and identify specific cell populations linked to better or worse outcomes, potentially paving the way for more personalized cancer treatment. Tao Ren, Ph.D., says, “This is the first kind of single-cell survival analysis that directly links individual tumor cells to patient outcomes”

Researchers find that elevated serotonin levels in the brain worsen tinnitus symptoms by activating a specific brain circuit that connects to the auditory system, suggesting that common antidepressants known as SSRIs may exacerbate tinnitus and pointing toward new possibilities for more targeted treatments. Laurence Trussell, Ph.D., says, “People with tinnitus should work with their prescribing physician to find a drug regimen that gives them a balance between relief of psychiatric symptoms, like depression and anxiety, while minimizing the experience of tinnitus. This study highlights the importance of clinicians recognizing and validating patient reports of medication-associated increases in tinnitus.”

Researchers find that elevated serotonin levels in the brain worsen tinnitus symptoms by activating a specific brain circuit that connects to the auditory system, suggesting that common antidepressants known as SSRIs may exacerbate tinnitus and pointing toward new possibilities for more targeted treatments. Laurence Trussell, Ph.D., says, “People with tinnitus should work with their prescribing physician to find a drug regimen that gives them a balance between relief of psychiatric symptoms, like depression and anxiety, while minimizing the experience of tinnitus. This study highlights the importance of clinicians recognizing and validating patient reports of medication-associated increases in tinnitus.”

Researchers find that elevated serotonin levels in the brain worsen tinnitus symptoms by activating a specific brain circuit that connects to the auditory system, suggesting that common antidepressants known as SSRIs may exacerbate tinnitus and pointing toward new possibilities for more targeted treatments. Laurence Trussell, Ph.D., says, “People with tinnitus should work with their prescribing physician to find a drug regimen that gives them a balance between relief of psychiatric symptoms, like depression and anxiety, while minimizing the experience of tinnitus. This study highlights the importance of clinicians recognizing and validating patient reports of medication-associated increases in tinnitus.”

On the podcast Come Together, Larry Sherman, Ph.D., talks about a recent study identifying an enzyme that could be a target to heal or slow the progression of neurodegenerative conditions like Alzheimer’s disease: “We found out that if you blocked that enzyme’s activity, that hyaluronic base, we can actually see repair in the brain.” He also talks about the role of music in sustaining brain health.