Embryo development following co-injection of a gene-correcting enzyme with sperm carrying a hypertrophic cardiomyopathy mutation, as described in a Nature study demonstrating mutation repair at fertilization to prevent transmission to future generations. (OHSU)

Germline editing. (OHSU)

Eliminating mosaicism in gene editing. (OHSU)

Germline editing image (PN 1) depicting the first sign of successful in vitro fertilization after co-injection with a gene-correcting enzyme and sperm carrying a hypertrophic cardiomyopathy mutation. (OHSU)

This image of germline editing (D2-1) shows individual blastomeres in early embryos two days after co-injection. Initiating repair at fertilization resulted in uniformly mutation-free cells throughout the developing embryos, as demonstrated in a recent study. (OHSU)

This germline editing image (Blastocyst 3) shows embryos developing into blastocysts after co-injection, a stage that could inform future approaches to helping families avoid inherited genetic disease. (OHSU)

Press conference with Shoukhrat Mitalipov, Ph.D., and Sanjiv Kaul, M.D., at OHSU, August 2, 2017. (OHSU)

Interview footage of Shoukhrat Mitalipov, Ph.D., at Oregon Health & Science University. (OHSU)

This video of germline editing compares S-phase (post-fertilization) CRISPR/Cas9 injection with M-phase co-injection of a gene-correcting enzyme and sperm from a donor with a disease-causing mutation. Initiating repair at fertilization was shown by OHSU researchers to eliminate mosaicism and correct the mutation in developing embryos. (OHSU)